Sökning: "Patrick Young"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Patrick Young.
1. Investigating the activation and regulation of the proteasome : an essential proteolytic complex
Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER
2. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Sammanfattning : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. LÄS MER
3. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation
Sammanfattning : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. LÄS MER
4. Studies of metazoan proteasome function and regulation
Sammanfattning : Biological processes depend upon the structural and functional quality of the molecules that comprise living organisms. The integrity of molecules such as DNA, RNA, proteins, carbohydrates and lipids is crucial and the precise three-dimensional shape and the detailed chemistry of these molecules orchestrate the biochemical processes vital for life. LÄS MER
5. Methods and models for 2D and 3D image analysis in microscopy, in particular for the study of muscle cells
Sammanfattning : Many research questions in biological research lead to numerous microscope images that need to be evaluated. Here digital image cytometry, i.e., quantitative, automated or semi-automated analysis of the images is an important rapidly growing discipline. LÄS MER
