Sökning: "protein stability"

Visar resultat 1 - 5 av 497 avhandlingar innehållade orden protein stability.

  1. 1. Molecular principles of protein stability and protein-protein interactions

    Detta är en avhandling från Stockholm : KTH

    Författare :Christofer Lendel; KTH.; [2005]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

  2. 2. Perplexing Protein Puzzles

    Detta är en avhandling från Department of Biophysical Chemistry, Lund University

    Författare :Stina Lindman; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; calbindin D9k; split-GFP; protein G B1; pKa-values; protein reconstitution; Electrostatic interactions; protein stability; protein denaturation; heteronuclear NMR; pH titrations;

    Sammanfattning : Protein structure and stability are inherent in the amino acid sequence and governed by non-covalent interactions. The cooperation between forces is, however, perplexing and not well understood. In order to elucidate and predict protein folding and stability, detailed studies of non-covalent interactions are required. LÄS MER

  3. 3. Unravelling protein stability and aggregation

    Detta är en avhandling från Media-Tryck, Lund University, Sweden

    Författare :Tanja Weiffert; [2018-10]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

    Sammanfattning : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. LÄS MER

  4. 4. Structure determination and thermodynamic stabilization of an engineered protein-protein complex

    Detta är en avhandling från Stockholm : KTH

    Författare :Elisabet Wahlberg; KTH.; [2006]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; protein structure; coupled folding; NMR spectroscopy; protein stability; protein-protein interactions; binding thermodynamics; isothermal titration calorimetry; protein engineering; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Sammanfattning : The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. LÄS MER

  5. 5. The birth and growth of the protein folding nucleus Studies of protein folding focused on critical contacts, topology and ionic interactions

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Linda Hedberg; Stockholms universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; chevron plot; transition-state movements; Hammond behaviour; topology; electrostatic interactions; pH dependence; mass-action; protein engineering; pKa; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Sammanfattning : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. LÄS MER