Sökning: "Protein C"

Visar resultat 1 - 5 av 1854 avhandlingar innehållade orden Protein C.

  1. 1. Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

    Författare :Samuel C C Chiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated with development of a hyperinflammatory syndrome termed hemophagocytic lymphohistiocytosis (HLH). LÄS MER

  3. 2. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

    Författare :Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

    Sammanfattning : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. LÄS MER

  4. 3. Modelling the Protein-DNA Interface

    Författare :Malin Lüking; Shina C. Lynn Kamerlin; Ehmke Pohl; Uppsala universitet; []
    Nyckelord :Protein-DNA interactions; Molecular Dynamics; Coarse-grained simulations; gene regulation; Biokemi; Biochemistry;

    Sammanfattning : Protein-DNA interactions are crucial to life. Several millions of DNA base pair steps are organ- ised, read and protected by proteins in every cell. Protein-DNA interactions must be specific, controllable and reasonably fast. Understanding how these features coexist is one of the great challenges for biochemists and molecular biologists. LÄS MER

  5. 4. The Mussel Adhesive Protein (Mefp-1) : A GREEN Corrosion Inhibitor

    Författare :Fan Zhang; Jinshan Pan; Douglas C. Hansen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbon steel; mussel adhesive protein; Mefp-1; inhibitor; adsorption; film forming; complexation; cross-linking; ceria nanoparticle; composite film; EIS; AFM; QCM-D; ATR-FTIR; Confocal Raman Micro-spectroscopy; DFT calculation;

    Sammanfattning : Corrosion of metallic materials is a natural process, and our study shows that even in an alkaline environment severe corrosion may occur on a carbon steel surface. While corrosion cannot be stopped it can be retarded. LÄS MER

  7. 5. Accuracy of mRNA Translation in Bacterial Protein Synthesis

    Författare :Jingji Zhang; Måns Ehrenberg; Olke C. Uhlenbeck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; genetic code; misreading; error hot spots; kinetics; aminoglycoside; Biokemi; Biochemistry;

    Sammanfattning : Reading of messenger RNA (mRNA) by aminoacyl-tRNAs (aa-tRNAs) on the ribosomes in the bacterial cell occurs with high accuracy. It follows from the physical chemistry of enzymatic reactions that there must be a trade-off between rate and accuracy of initial tRNA selection in protein synthesis: when the current accuracy, the A-value, approaches its maximal possible value, the d-value, the kinetic efficiency of the reaction approaches zero. LÄS MER