Sökning: "specificity"

Visar resultat 1 - 5 av 1364 avhandlingar innehållade ordet specificity.

  1. 1. Haematopoietic Serine Proteases : A Cleavage Specificity Analysis

    Författare :Michael Thorpe; Lars Hellman; Urban Gullberg; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

    Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER

  2. 2. PARN – The Tail End : Function and mechanisms of specificity and processivity

    Författare :Mikael Nissbeck; Anders Virtanen; Renée Schroeder; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Poly A specific ribonuclease; Adenosine; Specificity; Processivty; Telomere biology disorders; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Poly(A)-specific ribonuclease (PARN) is an exoribonuclease that is processive, poly(A) specific and cap-binding. PARN deadenylates the poly(A) tails present on a subset of mRNAs and non-coding RNAs, including among others certain snoRNAs, miRNAs and precursor rRNAs. LÄS MER

  3. 3. Characterization of antibody specificity using peptide array technologies

    Författare :Björn Forsström; Mathias Uhlén; Markus Templin; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Antibody; Epitope mapping; Peptide array; Suspension bead array; Antigen; Specificity; Cross-reactivity; Immunization; Immunogenicity; Biotechnology; Bioteknologi;

    Sammanfattning : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. LÄS MER

  4. 4. Substrate specificity of protein kinases studied with synthetic peptides

    Författare :Reet Toomik; Uppsala universitet; []
    Nyckelord :Medical sciences; protein kinase A; protein kinase C; substrate; peptide; specificity; stereospecificity; assay; SPOTS peptides; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : This thesis concentrates on the substrate specificities of protein kinases A and C (PKA, PKC). Synthetic peptides are used for that purpose, both in soluble and cellulose membrane-bound form. The, stereospecificity of both protein kinases was studied with D-amino acid containing synthetic peptides. LÄS MER

  5. 5. Mellan löften om särart och krav på evidens : En studie av kunskap och kunskapssyn i socialt inriktade ideella, privata och offentliga organisationer

    Författare :Ulf Hammare; Tommy Lundström; Lars Svedberg; Lars-Erik Olsson; Ersta Sköndal högskola; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; social work; academisation; professionalization; scientifically produced knowledge; Socialt arbete; akademisering; professionalisering; vetenskaplig kunskap; expertis; evidensbaserad praktik; särart; mångfald; komparerande perspektiv; ideell sektor; privat sektor; offentlig sektor; expertise; evidence based practice; increased diversity; specificity; comparative perspective; non-profit; private; public sector; questionnaire; socialt arbete; Social Work;

    Sammanfattning : Between the Promise of Specificity and the Demand for Evidence – A study of knowledge and the approach to knowledge in socially oriented non-profit, private and public sector organizationsIn the social work field it is possible to identify two parallel processes in time. On the one hand a qualitative developmental process―even towards a form of standardization―where central concepts are academisation, professionalization, scientifically produced knowledge, expertise and evidence based methods. LÄS MER