Sökning: "nerve transection"

Visar resultat 21 - 25 av 38 avhandlingar innehållade orden nerve transection.

  1. 21. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain

    Författare :Paola Tirassa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NGF; BDNF; CCK-8; glutamate; GABA; CCK receptors; hypothamalus; hippocampus; Choline Acetyltransferase; fimibria-fornix transection; vagotomy; vagal stimulation; RT-PCR; ELISA;

    Sammanfattning : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). LÄS MER

  3. 22. Expression and regulation of neuronal messenger molecules : focus on the NO-cGMP pathway and galanin in autonomic and sensory neurons

    Författare :Kristina Holmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adrenal gland; autonomic ganglia; cGMP; dorsal root ganglion; galanin; immunohistochemistry; in situ hybridization; nerve growth factor; neuropeptides; nitric oxide synthase; sodium nitroprusside; transgenic mice;

    Sammanfattning : The autonomic nervous system consists of the sympathetic, parasympathetic and enteric divisions. The sympathetic pre- and paravertebral neurons are in principle of noradrenergic phenotype. However, originally pharmacological experiments indicated that sympathetic fibers projecting to the sweat glands are cholinergic. LÄS MER

  4. 23. Regulation of CGRP expression in rat spinal motoneurons

    Författare :Fredrik Piehl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immunohistochemistry; in situ hybridization; motoneuron; axotomy; peptides; CGRP; trophic factor; FGF; IGF; BDNF; CNTF; GAP-43; cell culture; plasticity; mRNAregulation; regeneration;

    Sammanfattning : The normal distribution and lesion-induced changes in the expression of neuropeptides and growth-related proteins, with special reference to calcitonin gene-related peptide (CGRP),were studied in the motor system of the rat. In addition, factors that influence the expression of CGRP in motoneurons were identified. LÄS MER

  5. 24. Pituitary Adenylate Cyclase Activating Peptide (PACAP): An Experimental Study On the Expression and Regulation in the Peripheral Nervous System

    Författare :Kristian Moller; Neuroendokrin cellbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokemi; histokemi; Histologi; vävnadskultur; Histology; cytochemistry; histochemistry; tissue culture;

    Sammanfattning : This thesis deals with PACAP and PACAP type-1 receptors in the sensory and autonomic parts of the peripheral nervous system. In the rat, PACAP is expressed in small-sized sensory neurons and in C-fibers. LÄS MER

  7. 25. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

    Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

    Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER