Sökning: "transgenic mice"
Visar resultat 1 - 5 av 369 avhandlingar innehållade orden transgenic mice.
1. Of mice and men : SOD1 associated human amyotrophic lateral sclerosis and transgenic mouse models
Sammanfattning : Amyotrophic lateral sclerosis, ALS, is a progressive fatal neurodegenerative disorder affecting motor neurones in motor cortex, brain stem and spinal cord. This inevitably leads to paralysis, respiratory failure and death. LÄS MER
2. Effects of growth hormone on bone tissue in transgenic mice
Sammanfattning : Growth hormone (GH) affect bone-tissue in both humans and rodents. Also sex steroids are important for growth and the maintenance of normal bone physiology. The specific aims of this study were to investigate how high levels of GH affects bone tissue in mice and to determine whether these effects are dependent on an intact gonadal function. LÄS MER
3. Molecular characterization of prostate hyperplasia in prolactin transgenic mice
Sammanfattning : Benign prostatic hyperplasia (BPH) and prostate cancer are age-related diseases, affecting a majority of elderly men in the western world, and are known to be influenced by several different hormones, including sex hormones. Although the hormone prolactin (PRL) is well known to exert trophic effects on prostate cells, its involvement in the pathophysiology is still poorly characterized. LÄS MER
4. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice
Sammanfattning : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. LÄS MER
5. Cardiovascular effects of growth hormone. Studies in genetically engineered mice
Sammanfattning : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. LÄS MER