Sökning: "NMDA"

Visar resultat 1 - 5 av 151 avhandlingar innehållade ordet NMDA.

  1. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Författare :Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Nyckelord :Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Sammanfattning : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. LÄS MER

  2. 2. Chemical and stimulus-induced NMDA-dependent plasticity and the possible involved mechanisms

    Författare :Rui Li; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; NR2A; NR2B;

    Sammanfattning : Long-term potentiation (LTP) and long-term depression (LTD) are considered as the most important forms of synaptic plasticity involved in learning and memory. The traditional way to induce LTP and LTD is by electric stimulation leading to activation of NMDA-R. LÄS MER

  3. 3. Short- and long-term neuronal plasticity in hippocampal CA1 region of rat

    Författare :Fen-Sheng Huang; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :glutamate; hippocampus; plasticity; synapse; LTP; LTD; AMPA; NMDA;

    Sammanfattning : The brain is highly plastic, displaying both short- and long-term changes, resulting from developmental processes as well as learning and memory. Moreover, short-term plasticity such as paired pulse facilitation and depression (PPF, PPD) have long been used to monitor the presynaptic versus postsynaptic changes occurring during more lasting processes such as long-term potentiation and depression (LTP, LTD). LÄS MER

  4. 4. N-acetylaspartate in brain - studies on efflux and function

    Författare :Mattias Tranberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :N-acetylaspartate; Hippocampal slice cultures; HPLC; NMDA; Excitotoxicity; Volume regulation; Canavan disease;

    Sammanfattning : N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. LÄS MER

  5. 5. Activity-dependent changes of synaptic transmission in a long-term perspective and processes involved

    Författare :Mikhail Dozmorov; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; protein synthesis;

    Sammanfattning : Synaptic plasticity is an essential property of the central nervous system. It is thought torepresent a mechanism for memory aquisition, storage and recall. The most well studied forms ofsynaptic plasticity are homosynaptic NMDAR-dependent LTP and LTD in the hippocampus inducedby specific patterns of electrical stimulation. LÄS MER