Sökning: "CNTF"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet CNTF.

1. 1. Signaling mechanisms underlying neural stem cell differentiation. Implications of BMPs, retinoids, and MAP kinases

   Författare :Roland Faigle; Göteborgs universitet; []
   Nyckelord :neural stem cells; differentiation; BMP; ASK1; p38 MAP kinase; CNTF; retinoic acid;

   Sammanfattning : Introduction: Neural stem cells are proliferating cells, derived from the nervous system with the ability to give rise to neurons, astrocytes, and oligodendrocytes. The molecular events and signaling pathways regulating neural stem cell differentiation are largely unknown. LÄS MER

3. 2. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

   Författare :Maria A I Åberg; Göteborgs universitet; []
   Nyckelord :Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

   Sammanfattning : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. LÄS MER

4. 3. Spinal cord grafts : interaction with cografts and effects of trophic factors

   Författare :Katarzyna Trok; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cord injury; spinal cord transplants; regeneration; GDNF; neurotrophins; CNTF; 5HT; immunohistochemistryKatarzyna Trok; 1996ISBN 91-6;

   Sammanfattning : Spinal cord injury is common in the modern society, often afflicts young individuals, and often has devastating consequences. The present work studies possibilities to obtain better conditions for regeneration of the transected spinal cord in rats, conditions under which spinal cord grafts are able to establish structural and functional connections with "natural" targets, and effects of a series of neurotrophic factors on spinal cord graft survival and growth. LÄS MER

5. 4. Regulation of CGRP expression in rat spinal motoneurons

   Författare :Fredrik Piehl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immunohistochemistry; in situ hybridization; motoneuron; axotomy; peptides; CGRP; trophic factor; FGF; IGF; BDNF; CNTF; GAP-43; cell culture; plasticity; mRNAregulation; regeneration;

   Sammanfattning : The normal distribution and lesion-induced changes in the expression of neuropeptides and growth-related proteins, with special reference to calcitonin gene-related peptide (CGRP),were studied in the motor system of the rat. In addition, factors that influence the expression of CGRP in motoneurons were identified. LÄS MER

7. 5. On the actions of neurotrophic factors on the chromaffin cells of the adrenal medulla

   Författare :Petter Förander; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neural crest; chromaffin cells; neurotrophic factors; NGF; NT-3; NT4; CNTF; GDNF; TGFß; FGF2; glucocorticoids; Intra oculartransplantation ; primary cultures; neurite outgrowth;

   Sammanfattning : Chromaffin cells producing adrenaline or noradrenaline are the predominant cell type in the adrenal medulla, but ganglion cells and Schwann cells are also present. All cells of the adrenal medulla are derived from the neural crest, which is a transient neuroectoderm-derived embryonic structure. LÄS MER