Sökning: "CCK-8"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet CCK-8.

  1. 1. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain

    Författare :Paola Tirassa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NGF; BDNF; CCK-8; glutamate; GABA; CCK receptors; hypothamalus; hippocampus; Choline Acetyltransferase; fimibria-fornix transection; vagotomy; vagal stimulation; RT-PCR; ELISA;

    Sammanfattning : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). LÄS MER

  3. 2. Cholecystokinin, dopamine and glutamate in subcortical and peripheral control of food intake

    Författare :Min Qian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cholecystokinin; dopamine; glutamate; food intake;

    Sammanfattning : This thesis analyzes some of the mechanisms whereby cholecystokinin octapeptide (CCK-8) inhibits food intake in male rats. Depletion of monoamines using reserpine blocked the capacity for ingestive responses. These responses were restored in reserpinized rats by treatment with the non-competitive N-methyl-D-aspartate receptor antagonist MK-801. LÄS MER

  4. 3. Neuro-immune communication: role of the vagus nerve : an electrophysiological study

    Författare :Violeta Bucinskaite; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cholecystokinin; CCKA; CCKB; cytokines; IL-1[beta]; illness; nerve activity; NIDDM; OLETF; the vagus; vagotomy;

    Sammanfattning : Defence mechanisms involve close interactions between the nervous and immune systems following an immune challenge. The vagal pathways which modulate major visceral functions under normal conditions are also important neural pathways for the transmission of information on peripheral conditions to the CNS. LÄS MER

  5. 4. The influence of nitric oxide and cholecystokinin on tissue homeostasis in exocrine pancreas : an experimental study in rats

    Författare :Lena Trulsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Growth of the pancreas is stimulated by cholecystokinin (CCK) in rats. Nitric oxide (NO), which is synthesized from the amino acid L-arginine by NO-synthases (NOS), interferes with CCK in modulating the pancreatic secretion. LÄS MER

  7. 5. Factors inhibiting ingestive behavior in chronic renal failure

    Författare :Abdel-Hafiz Mamoun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :rat; uremia; cholecystokinin octapeptide; nitric oxide; leptin; glucose; amino acids; anorexia; ingestive behavior; peritoneal dialysis solutions; hemodialysis;

    Sammanfattning : Protein-energy malnutrition and wasting occur in many patients with chronic renal failure. Reduced nutrient intake because of anorexia, nausea and vomiting, caused by uremic toxicity is an important factor. LÄS MER