Sökning: "Choline Acetyltransferase"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Choline Acetyltransferase.

  1. 1. Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents

    Författare :Helene Hall; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-synuclein; animal model; choline acetyltransferase; cholinergic neurons; cognition; dementia; dopaminergic neurons; Lewy bodies; Parkinson s disease; magnetic resonance spectroscopy;

    Sammanfattning : Motor symptoms are currently considered the first clinical hallmark of Parkinson’s disease (PD). They develop as a result of dopamine loss in the striatum, subsequent to the progressive neurodegeneration of dopamin- ergic neurons in the substantia nigra. LÄS MER

  3. 2. Mechanisms of cell type-specific gene transcription : studies on the choline acetyltransferase gene

    Författare :Peter Lönnerberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Choline acetyltransferase (ChAT) is the enzyme synthesizing the neurotransmitter acetylcholine. Previous studies from our laboratory on the regulation of the cholinergic phenotype have suggested the presence of regulatory elements in the ChAT gene controlling accurate time- and cell-specific expression. LÄS MER

  4. 3. Cholinergic mechanisms in the spinal cord : topographical localizations of choline acetyltransferase and neuroreceptors and their changes in amyotrophic lateral sclerosis

    Författare :Per-Göran Gillberg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain

    Författare :Paola Tirassa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NGF; BDNF; CCK-8; glutamate; GABA; CCK receptors; hypothamalus; hippocampus; Choline Acetyltransferase; fimibria-fornix transection; vagotomy; vagal stimulation; RT-PCR; ELISA;

    Sammanfattning : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). LÄS MER

  7. 5. Analysis of organic and inorganic arsenicals in biological material

    Författare :Harald Norin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Arsenobetaine; arsenocholine; acetylarsenocholine; pyrolysis gas chromatography; atomic absorption spectrophotometry; mass spectrometry; nuclear magnetic resonance spectrometry;

    Sammanfattning : An analytical method for measurement of the urinary metabolites of inorganic arsenic is presented. Increased concentrations of urinary metabolites of inorganic arsenic are indicative of occupational exposure. Organoarsenic compounds in the urine from seafood intake do not affect the analytical results. LÄS MER