Sökning: "motoneuron"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet motoneuron.

  1. 1. Upper and Lower Motoneuron Lesions in Tetraplegia - Diagnostic and Therapeutic Implications of Electrical Stimulation

    Författare :Ines Bersch; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electrical stimulation; Tetraplegia; Upper motoneuron lesion; Lower motoneuron lesion; Motor point topography; Nerve transfer;

    Sammanfattning : The overall objective of this thesis was to improve outcomes and predictability of the treatment of upper extremity function in patients with cervical spinal cord injury and tetraplegia by advancing the diagnostic and therapeutic tools employed in upper and lower motor neuron lesions. An overview is presented of the current knowledge about the principles of electrical stimulation and its usefulness and proven effects on the upper limb. LÄS MER

  2. 2. Adhesion molecules and synapse remodeling during motoneuron regeneration

    Författare :Johan Zelano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Spinal motoneurons integrate a vast synaptic input and are the final conveyors of motor commands to skeletal muscle. Motoneuron regeneration includes altered contacts between the motoneuron and several other cell types. LÄS MER

  3. 3. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

    Författare :Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

    Sammanfattning : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. LÄS MER

  4. 4. Genetics and inflammation in nerve injury-induced neurodegeneration

    Författare :Olle Lidman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Axotomy; Motoneuron; Neurodegeneration; Immunity; Microglia; MHC; QTL Mapping.;

    Sammanfattning : Neurodegeneration and inflammation are characteristic of many diseases of the central nervous system (CNS) and understanding the molecular networks that regulate these processes is of central importance for the development of effective therapies. Although the CNS has traditionally been regarded as an immuno privileged organ, immune reactions, including components of both local innate and systemic immunity, do occur in this tissue. LÄS MER

  5. 5. On VEGF and related factors in neurotrauma

    Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

    Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER