Sökning: "insulin signaling"

Visar resultat 16 - 20 av 257 avhandlingar innehållade orden insulin signaling.

  1. 16. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    Författare :Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER

  3. 17. Regulation of insulin producing cells, stress responses and metabolism in Drosophila

    Författare :Neval Kapan; Dick R. Nässel; Alberto Ferrus; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Insulin signaling; Drosophila melanogaster; peptide hormones; neuropeptides; GABA; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, neuropeptides have regulatory roles in development, growth, metabolism and reproduction. This study focused on GABA and the neuropeptides Drosophila tachykinin (DTK), short neuropeptide F (sNPF), adipokinetic hormone (AKH), corazonin (CRZ) and Drosophila insulin-like peptides (DILPs) as possible regulators of metabolic stress responses and homeostasis. LÄS MER

  4. 18. Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes

    Författare :Daniel Saiepour; Per-Arne Oldenborg; Janove Sehlin; Olle Stendahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophil granulocytes; glucose; insulin; protein kinase C; diacylglycerol; phagocytosis; respiratory burst; diabetes; Histology; Histologi;

    Sammanfattning : Neutrophil granulocytes play an important role in the host defence against invading microorganisms and constitute the frontline of defence within the innate immune system and are among the first cells to arrive at the site of inflammation. Effective phagocytosis and killing of invading pathogens by neutrophils is of significant importance for successful resistance to infectious diseases. LÄS MER

  5. 19. Regulation of lipid metabolism in rat and 3T3-L1 adipocytes; Cross-talk between Insulin, the neuro-peptides PACAP/VIP and with B1-integrins

    Författare :Lina Åkesson; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; obesity; Insulin; diabetes;

    Sammanfattning : Type 2 Diabetes is a disorder that increases globally, but mainly in the western world. One of the hallmarks of Type 2 diabetes is insulin resistance in the target tissues of insulin action (adipose tissue, liver and skeletal muscle). In addition, most patients with Type 2 diabetes are obese. LÄS MER

  7. 20. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms

    Författare :Sabine Uhles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin receptor; signal transduction; gene expression regulation; insulin; glucokinase; cfos; pancreatic beta cell; membrane microdomains; green fluorescent protein.;

    Sammanfattning : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. LÄS MER