Sökning: "exendin- 9-39"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden exendin- 9-39.
1. Studies of cAMP and Ca2+ signaling in pancreatic islet cells
Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER
2. Role of GLP-1 receptor agonists in endothelial function
Sammanfattning : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. LÄS MER
3. On endothelial function in type 2 diabetic patients with coronary artery disease
Sammanfattning : Patients with type 2 diabetes have a poor outcome suffering a myocardial infarction (MI). Endothelial dysfunction may play a role in this poor prognosis. In type 2 diabetes, endothelial dysfunction is a salient feature coexisting with obesity and insulin resistance and may be linked by the same pathophysiology, i.e. LÄS MER
4. Gut peptides in gastrointestinal motility and mucosal permeability
Sammanfattning : Gut regulatory peptides, such as neuropeptides and incretins, play important roles in hunger, satiety and gastrointestinal motility, and possibly mucosal permeability. Many peptides secreted by myenteric nerves that regulate motor control are also produced in mucosal epithelial cells. LÄS MER
5. Remote ischemic conditioning to protect the heart in myocardial infarction : therapeutic intervention and underlying mechanisms
Sammanfattning : Background: Urgent reperfusion of the occluded coronary artery halts the ischemic insult to the myocardium and is the single most important action to limit infarct size in ST-elevation myocardial infarction. However, reperfusion itself introduces an additional threat to the recovering ischemic myocardium whereby still viable cardiomyocytes suffer additional irreversible damage. LÄS MER