Sökning: "insulin signaling"

Visar resultat 21 - 25 av 257 avhandlingar innehållade orden insulin signaling.

  1. 21. Insulin resistance in pancreatic cancer

    Författare :Bengt Isaksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pancreatic cancer; glucose transport; glucose metabolism; insulin signaling; insulin resistance; uncoupling proteins; obstructive jaundice; IAPP; risk factors.;

    Sammanfattning : The dismal prognosis of pancreatic cancer (PC) is related to metabolic complications of the tumor. Impaired glucose tolerance or diabetes due to insulin resistance, and cachexia are observed early and frequently in these patients. The basic mechanisms of PC-associated insulin resistance and weight loss are not fully understood. LÄS MER

  3. 22. Insulin Signaling in Human Adipocytes a Systems Biology Approach

    Författare :Cecilia Brännmark; Peter Strålfors; Gunnar Cedersund; Peter Arner; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Obesity and a sedentary life style are associated with type 2 diabetes, a disease starting with insulin resistance in the adipose tissue, which spreads to the whole body. Despite large research efforts to understand the insulin signaling system, there is little knowledge of the mechanisms behind insulin resistance and type 2 diabetes developments. LÄS MER

  4. 23. Mechanisms of insulin signaling and the role of caveolae

    Författare :Santiago Parpal; Pam Fredman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin regulates metabolic as well as mitogenic processes in target cells, involving a large number of mediators of signal transduction. In its role as a growth factor, insulin stimulates cell growth, in a process we demonstrate requires the participation of the Raf-1 kinase. LÄS MER

  5. 24. Epac2 signaling at the β-cell plasma membrane

    Författare :Ida Alenkvist; Anders Tengholm; Olga Göransson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-cell; insulin secretion; cAMP; Ca2 ; Epac; Rap; exocytosis; sulfonylurea; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. LÄS MER

  7. 25. The role of insulin signaling during development, reproductive diapause and aging in Drosophila Melanogaster

    Författare :Sifang Liao; Dick Nässel; Heinrich Dircksen; Mark Brown; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insulin-like peptides; reproductive diapause; behavioral senescence; neuromodulator; lifespan; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : The insulin/insulin-like growth factor signaling pathway exists from invertebrates to vertebrates and it can regulate various biological processes, including development, metabolism, stress resistance and lifespan. In Drosophila, eight insulin-like peptides (DILP1-8) have been found. LÄS MER