Sökning: "Anders Tengholm"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Anders Tengholm.
Sammanfattning : The Ca2+ion plays a fundamental role in the control of a variety of cellular functions, including insulinsecretion from pancreatic β-cells. Whereas the concentration of free Ca2+ in the cytoplasm ([Ca2+]i) ismaintained at low levels (5O-100 nM), some organelles contain high concentrations of the ion. LÄS MER
Sammanfattning : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. LÄS MER
Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER
Sammanfattning : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. LÄS MER
Sammanfattning : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. LÄS MER