Sökning: "Caspase"

Visar resultat 1 - 5 av 258 avhandlingar innehållade ordet Caspase.

  1. 1. Caspase-dependent and caspase-independent neuronal injury in the developing brain

    Författare :Changlian Zhu; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia ischemia; neonatal; cell death; caspase; apoptosis-inducing factor; brain; apoptosis; autophagy; nitric oxide;

    Sammanfattning : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. LÄS MER

  2. 2. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Detta är en avhandling från Stockholm : Department of Neurochemistry

    Författare :Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER

  3. 3. Caspase-3 in lens epithelium

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Nooshin Talebizadeh; Per Söderberg; Finn Hallböök; Konstantin Galichanin; Michael Wormstone; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ultraviolet radiation; caspase-3; lens; cataract; apoptosis; Immunohistochemistry; spatial distribution; time evolution; modelling; automatic analysis; cell counting; image analysis.; Ophtalmology; Oftalmiatrik;

    Sammanfattning : Purpose: To model the time evolution of active caspase-3 protein expression in a healthy lens, and in a lens exposed to UVR-300 nm (UVR-B). To develop an automated method to classify the fluorescent signal of biomarkers in the lens epithelial cells.Methods: Six-week old Sprague-Dawley rats were used. LÄS MER

  4. 4. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hanna Wootz; Uppsala universitet.; [2006]
    Nyckelord :Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. LÄS MER

  5. 5. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Frida Abel; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; child; cancer; neuroectodermal; neural crest; loss of heterozygosity; LOH; bcl-2; mcl-1; apaf-1; caspase-2; caspase-3; caspase-9; PIN; DLC-1; caspase-2; loss of heterozygosity; cancer; caspase-9; bcl-2; mcl-1; neural crest; DLC-1; caspase-3; neuroectodermal; PIN; LOH; apaf-1;

    Sammanfattning : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. LÄS MER