Sökning: "cytoplasmic and nuclear"

Visar resultat 36 - 40 av 122 avhandlingar innehållade orden cytoplasmic and nuclear.

  1. 36. Mitochondria, contractility and Ca2+ handling : cardiac and skeletal muscle adaptations in health and disease

    Författare :Daniel C Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Contractility is a fundamental feature of skeletal and cardiac muscles. An indispensable step in the cellular signal for contraction is a transient elevation in cytoplasmic free [Ca2+] ([Ca2+]i). Both the production of contractile force and Ca2+ handling processes are highly energy demanding. LÄS MER

  3. 37. Studies of penta-decameric binding proteins: AP-4 and CBF-A

    Författare :Alaitz Aranburu; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; transplantation; Metabolism; serologi; metabolism; Biokemi; serology; Immunology; hnRNP H; NPM; CBF-A; AP-4; transcription; B cells; immunoglobulin; Immunologi;

    Sammanfattning : Each immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. LÄS MER

  4. 38. Dynamic protein trafficking of the nuclear membrane and in peroxisomes

    Författare :Charlotta Buch; Einar Hallberg; Howard J. Worman; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear pore complexes (NPCs) in a selective and energy dependent manner. LÄS MER

  5. 39. Experimental radioimmunotherapy and effector mechanisms

    Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

    Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

  7. 40. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Författare :Syrina Mehrabi; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Sammanfattning : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. LÄS MER