Sökning: "transcription"

Visar resultat 1 - 5 av 1766 avhandlingar innehållade ordet transcription.

  1. 1. Regulation of immunoglobulin transcription

    Detta är en avhandling från BMC Biomedical Centre, Lund University

    Författare :David Liberg; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; N-substituted benzamides; NFkB; transcription; B cells; immunoglobulin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Each Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. LÄS MER

  2. 2. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; [2007]
    Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER

  3. 3. Maf transcription factors in beta cell function

    Detta är en avhandling från Stem Cell Center, Lund University

    Författare :Elvira Ganic; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Sammanfattning : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. LÄS MER

  4. 4. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marina Tshuikina Wiklander; Fredrik Öberg; Kenneth Nilsson; Ugo Testa; [2008]
    Nyckelord :Medical sciences; IRF family; ICSBP IRF8; epigenetics; ATRA; TNFα; histone modifications; methylation; transcription; MEDICIN OCH VÅRD;

    Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER

  5. 5. Exploring and predicting DNA template dependent variation in transcription

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Harriet Mellenius; Måns Ehrenberg; Johan Elf; Dan Andersson; Otto Berg; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcription; accuracy; kinetic proofreading; selection; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Reliable transmission of information from DNA to proteins is a pre-requisite for all life, where substitution errors in the polypeptide chain may arise from transcription, aminoacylation of tRNAs or translation. The fidelity control mechanisms in transcription have nevertheless received little attention, based on the assumption that the transcriptional error is masked by the translational error. LÄS MER