Sökning: "clearance"

Visar resultat 21 - 25 av 622 avhandlingar innehållade ordet clearance.

  1. 21. Deposition and absorption of inhaled drugs

    Författare :Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

    Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER

  3. 22. The Hydrodynamics of Waterjet/Hull Interaction

    Författare :Arash Eslamdoost; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; trim angle; vena-contracta; transom clearance; net thrust; waterjet hull interaction; waterjet propulsion; capture area; exit drag; non-linear free-surface; intake drag; gross thrust; sinkage; streamtube; RANS; thrust deduction; potential flow; VOF;

    Sammanfattning : The objective of the present investigation is to explore the physics behind the waterjet/hull interaction, and in particular the negative thrust deduction often reported in the semi-planing speed range. Another objective is to propose a validated numerical technique for computing the hydrodynamics of waterjet-driven hulls. LÄS MER

  4. 23. Aspects of retransfusion of shed blood in cardiac surgery

    Författare :Björn Brondén; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CABG; cardiotomy suction; lipid microemboli; porcine study; clinical study; cystatin C; creatinine; iohexol clearance; outcome; retransfusion; transfusion; blood.;

    Sammanfattning : The use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. LÄS MER

  5. 24. Modelling and Simulation to Improve Antimalarial Therapy

    Författare :Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. LÄS MER

  7. 25. Radiolabeled acetate PET in oncology imaging : studies on head and neck cancer, prostate cancer and normal distribution

    Författare :Aijun Sun; Jens Sörensen; Silvia Johansson; Mikael Karlsson; Katrine Åhlström Riklund; Ingela Turesson; Heikki Minn; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11C-acetate; 18F-fluoroacetate; PET; head and neck cancer; staging; delineating tumor volume; clearance rate; perfusion; RT; treatment outcome; benign and malignant lymph node; prostate cancer; normal distribution; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : The use of positron emission tomography (PET) for imaging in oncology has grown rapidly in recent years. 2-[18F]-fluorodeoxyglucose (FDG) is the most common tracer of PET, although drawbacks exist. LÄS MER