Sökning: "intermittent preventive therapy"

Hittade 4 avhandlingar innehållade orden intermittent preventive therapy.

  1. 1. Modelling and Simulation to Improve Antimalarial Therapy

    Författare :Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. LÄS MER

  3. 2. Optimization of intermittent preventive therapy for malaria during pregnancy : effectiveness of dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine

    Författare :Eulambius Mathias Mlugu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is a Tropical disease caused by different parasites species of genius Plasmodium. Because of pregnancy associated lowered immunity, women who are pregnant are at higher risk to malaria infection than non-pregnant women. LÄS MER

  4. 3. Screening for atrial fibrillation in high-risk individuals : a stroke preventive effort

    Författare :Emma Svennberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : INTRODUCTION: A condition can be suitable for population screening if the disease is an important health problem, can be detected by an appropriate test and has a silent/latent stage during which treatment could be initiated in order to prevent consequences of the disease. Atrial fibrillation (AF) increases the risk of ischemic stroke 5-fold, a risk that can be reduced by at least 64% by the use of stroke-preventive, oral anticoagulant (OAC) therapy, and there are several non-invasive methods that can be used to diagnose AF. LÄS MER

  5. 4. Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs

    Författare :Sabina Dahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Half of the world's population live at risk for malaria and nearly one million people die from the disease every year. The malaria burden is greatest in children and pregnant women in sub-Saharan Africa. LÄS MER