Sökning: "Ingela Turesson"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Ingela Turesson.

1. 1. Epidermal Melanocyte Response to Radiotherapy

   Författare :Per Fessé; Henrik Lindman; Ingela Turesson; Johan Ahlgren; Jan Nyman; Catharine West; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanocytes; fractionated radiotherapy; ΔNp63; MITF; PAX3; SOX10; p53; p21; BMI1; pRb; CXCR2; DNA-DSB; 53BP1; CXCR2;

   Sammanfattning : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. LÄS MER

3. 2. Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy

   Författare :Anna Pettersson; Ingela Turesson; Birgitta Johansson; Christina Persson; Clare Shaw; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dietary intervention; gastrointestinal symptoms; prostate cancer; radiotherapy; randomized controlled trial; health-related quality of life; questionnaire design; nutritional assessment; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Objective The main objective of this thesis was to explore the effects of diet on gastrointestinal symptoms in prostate cancer patients treated with local curative radiotherapy, by evaluating dietary intake prior to treatment (Study I), the psychometric properties of a new questionnaire on patient-reported gastrointestinal side effects (Study II), and the effect of a dietary intervention on acute and long-term gastrointestinal symptoms up to 2 years after radiotherapy completion (Study III-IV).Methods A total of 130 men with localized prostate cancer referred to dose-escalated radiotherapy (ED2 87-102 Gy, α/β=3 Gy) were recruited to a dietary intervention trial. LÄS MER

4. 3. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

   Författare :Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER

5. 4. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

   Författare :Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

   Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER

7. 5. Radiolabeled acetate PET in oncology imaging : studies on head and neck cancer, prostate cancer and normal distribution

   Författare :Aijun Sun; Jens Sörensen; Silvia Johansson; Mikael Karlsson; Katrine Åhlström Riklund; Ingela Turesson; Heikki Minn; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11C-acetate; 18F-fluoroacetate; PET; head and neck cancer; staging; delineating tumor volume; clearance rate; perfusion; RT; treatment outcome; benign and malignant lymph node; prostate cancer; normal distribution; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : The use of positron emission tomography (PET) for imaging in oncology has grown rapidly in recent years. 2-[18F]-fluorodeoxyglucose (FDG) is the most common tracer of PET, although drawbacks exist. LÄS MER