Sökning: "clearance"

Visar resultat 16 - 20 av 622 avhandlingar innehållade ordet clearance.

  1. 16. Proteomics-informed analysis of drug disposition in the human liver and small intestine

    Författare :Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER

  3. 17. Intraperitoneal 5-Fluorouracil treatment of cancer - clinical and experimental studies

    Författare :Mikael Öman; Peter Naredi; Larsolof Hafström; Johan Permert; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intraperitoneal; 5-fluorouracil; pancreas cancer; vasopressin; Xenon-clearance; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Background:Pancreas cancer is a most aggressive malignancy. More than 80% of patients diagnosed with pancreas cancer, exhibit such advanced disease, that curative surgery is impossible. Systemic chemotherapy prolongs survival to 5-9 months. LÄS MER

  4. 18. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

    Författare :Elin Matsson; Hans Lennernäs; Lars Knutson; Ulf Eriksson; Kim Brouwer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Direct thrombin inhibitors; prodrugs; ximelagatran; AZD0837; erythromycin; ketoconazole; drug-drug interactions; hepatobiliary transport; biliary clearance; ATP-binding cassette; ABC transporters; solute carriers; SLC transporters; CYP3A4; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. LÄS MER

  5. 19. Heparin-binding protein and organ failure in critical illness

    Författare :Jonas Tydén; Joakim Johansson; Magnus Hultin; Jakob Walldén; Sören Berg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparin-binding protein; Critical care; Shock; Acute respiratory distress syndrome; Acute kidney injury; Ventilator induced lung injury; Renal clearance; Anaesthesiology; anestesiologi;

    Sammanfattning : Background: For patients severely ill enough to require care in an intensive care unit (ICU), both the disease itself (e.g. bacteria in the blood in sepsis or fractures after trauma) and effects of the immune system can cause circulatory, pulmonary, or renal dysfunction. Leukocytes play a dominant role in the immune system. LÄS MER

  7. 20. Monitoring of occupational exposure to antineoplastic drugs

    Författare :Maria Hedmer; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; industrial medicine; Occupational health; plasma; urine; renal clearance; risk evaluation; biological monitoring; air monitoring; wipe sampling; occupational exposure; ifosfamide; antineoplastic drugs; cyclophosphamide; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. LÄS MER