Sökning: "Pharmacokinetics and Drug Therapy"
Visar resultat 1 - 5 av 64 avhandlingar innehållade orden Pharmacokinetics and Drug Therapy.
1. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silicoDetta är en avhandling från Uppsala : Acta Universitatis Upsaliensis
Sammanfattning : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. LÄS MER
- Detta är en avhandling från Göteborg : Göteborg University
Sammanfattning : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. LÄS MER
- Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis
Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER
4. Pericyte Influence on Drug Delivery Across the Blood-Brain Barrier Implications for Therapy of Neurodegenerative DiseasesDetta är en avhandling från Uppsala : Acta Universitatis Upsaliensis
Sammanfattning : The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. LÄS MER
- Detta är en avhandling från Upppsala : Acta Universitatis Upsaliensis
Sammanfattning : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. LÄS MER