Sökning: "technetium-99m"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet technetium-99m.

1. 1. Deposition and absorption of inhaled drugs

   Författare :Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER

3. 2. Tick-borne encephalitis : on pathogenesis and prognosis

   Författare :Göran Günther; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Human; tick-borne encephalitis; viral; meningo-encephalitis; cerebrospinal fluid; PCR; cytokines; immunoglobulin; SPECT; technetium-99m-HMPAO;

   Sammanfattning : The general aim of the five studies presented in this thesis was to investigate the clinical outcome and prognosis and factors of importance for the pathogenesis of TBE compared to other aseptic meningo-encephalitis. In a prospective study 149 patients presenting with clinical symptoms of acute viral meningo-encephalitis between June 1991 and December 1993 were included. LÄS MER

4. 3. The impact of airway-irritating exposure and wet work on subjects with allergy or other sensitivity : epidemiology and mechanisms

   Författare :Pernilla Wiebert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Air pollution; allergic rhinitis; allergy; asthma; blood; carbonaceous; circulation; clearance; cohort; dermatitis; epidemiology; exposure assessment; Indium-111; inhalation; job-exposure matrix; lung; occupation; retention; Technegas generator; Technetium-99m; translocation; ultrafine particles;

   Sammanfattning : The prevalence of asthma and allergies is increasing, which means that the proportion of workers on the labour market with allergy or other sensitivity also increases. It is as of yet not known to what extent these persons with an elevated sensitivity in the airways or the skin are affected by exposure to irritating substances at work. LÄS MER

5. 4. Ulcerative colitis : Imaging of inflammation

   Författare :Sven Almer; Vibeke Binder; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Ulcerative colitis is a chronic inflannnatory disorder of unknown origin engaging the large bowel. Based on the need for accurate assessment of inflammation, three different non-invasive techniques, two leukocyte scintigraphy techniques and one radiological method, were evaluated in the assessment of active inflammation in altogether 131 patients with ulcerative colitis. LÄS MER

7. 5. Cardiac involvement in familial amyloidosis with polyneuropathy

   Författare :Peter Eriksson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloidosis; arrhythmias; cardiac pacing; cardiac radionuclide; imaging; echocardiography; electrocardiography; pathology;

   Sammanfattning : Familial amyloidosis with polyneuropathy (FAP) is a neuropathic form of heredofamilial systemic amyloidosis. Clusters of patients have been reported predominantly from Portugal, Japan and Sweden. The present study examines the involvement of the heart in individuals with the Swedish variety of FAP. LÄS MER