Sökning: "cystatin C"

Visar resultat 1 - 5 av 67 avhandlingar innehållade orden cystatin C.

  1. 1. L68Q cystatin C: Expression, cellular transport and turnover of the cystatin C variant forming amyloid in patients with Hereditary Cystatin C Amyloid Angiopaty (HCCAA)

    Detta är en avhandling från ILM, Department of Clinical Chemistry, Lund University Hospital, S-221 85 Lund, Sweden

    Författare :María Bjarnadóttir; Lund University.; Lunds universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cysteine proteinase inhibitor; brain haemorrhage; amyloid; cystatin C; HCCAA; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. LÄS MER

  2. 2. Cystatin C in the Eye and in Specific Model Systems

    Detta är en avhandling från Johan Wasselius, WRC, BMC B13, Klinikgatan 26, 22184 Lund

    Författare :Johan Wasselius; Lund University.; Lunds universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; protein uptake; ciliary body; lens; cornea; retina; eye; Cystatin C; cathepsin B; Oftalmologi;

    Sammanfattning : It is a necessity of life to make proteins, and it is an equal necessity to degrade those proteins, to eliminate dysfunctional proteins, and leave room for new ones. The processes of protein synthesis and degradation into peptides - proteolysis - have attracted a great interest during the last decades. LÄS MER

  3. 3. Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Sundelöf; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer´s disease; amyloid β-protein; cystatin C; cathepsin B; biomarkers; risk factors; epidemiology; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Geriatrics and medical gerontology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Geriatrik och medicinsk gerontologi; Medicin; Medicine;

    Sammanfattning : It is suggested that Alzheimer’s disease (AD) is caused by an imbalance between production, degradation and clearance of the amyloid-β (Aβ) protein. This imbalance leads to aggregation of Aβ and tau proteins and neurodegeneration in the brain. LÄS MER

  4. 4. Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy

    Detta är en avhandling från Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University

    Författare :Gustav Östner; Lund University.; Lunds universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystatin C; amyloid; amyloidosis; oligomers; domain swapping;

    Sammanfattning : The pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. LÄS MER

  5. 5. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor

    Detta är en avhandling från Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University

    Författare :Hanna Wallin; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin; cell line; co-localisation; cystatin C; internalisation; legumain;

    Sammanfattning : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. LÄS MER