Sökning: "solute carriers"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden solute carriers.

  1. 1. Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system

    Författare :Emilia Lekholm; Robert Fredriksson; Helgi B. Schiöth; David Drew; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Solute Carriers; transporter; amino acid starvation; glucose metabolism; MFS; SV2; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. LÄS MER

  3. 2. Atypical Solute Carriers : Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters

    Författare :Emelie Perland; Robert Fredriksson; Helgi Schiöth; Åsa Mackenzie; Sonchita Bagchi; Carsten Uhd Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Major facilitator superfamily; solute carrier; transporter; protein expression; mRNA expression; phylogenetic clustering; orthologues; co-expression; subcellular location; nutrition.; Neuroscience; Neurovetenskap;

    Sammanfattning : Solute carriers (SLCs) constitute the largest family of membrane-bound transporter proteins in humans, and they convey transport of nutrients, ions, drugs and waste over cellular membranes via facilitative diffusion, co-transport or exchange. Several SLCs are associated with diseases and their location in membranes and specific substrate transport makes them excellent as drug targets. LÄS MER

  4. 3. Characterization of Novel Solute Carriers in Humans, Mice and Flies : Solute Carriers in a Broad and Narrow Perspective

    Författare :Mikaela Ceder; Robert Fredriksson; Anita Öst; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC; Putative SLCs; Major facilitator superfamily; MFS; Drosophila melanogaster; Glucose metabolism; UNC93A; CG4928; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The solute carrier family is the largest family of membrane-bound transporters in humans, with 430 members divided into 65 subfamilies. They transport various substrates across lipid barriers and are vital for absorption, distribution, metabolism and excretion in all cell types in the body. LÄS MER

  5. 4. Characterization of Centrally Expressed Solute Carriers : Histological and Functional Studies with Transgenic Mice

    Författare :Sahar Roshanbin; Robert Fredriksson; David Engblom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLC; Solute carriers; Amino acid transporter; PAT; B0AT2; mTORC1; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The Solute Carrier (SLC) superfamily is the largest group of membrane-bound transporters, currently with 456 transporters in 52 families. Much remains unknown about the tissue distribution and function of many of these transporters. LÄS MER

  7. 5. Characterization of Amino Acid Transporters : Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38

    Författare :Sofie Victoria Hellsten; Robert Fredriksson; Gether Ulrik; Uppsala universitet; []
    Nyckelord :Solute carriers; amino acid transporter; SLC38 family; SLC38A8; SNAT8; SLC38A10; SNAT10; SLC38A9; SNAT9; amino acid starvation; AAR; mTORC1; Neuroscience; Neurovetenskap;

    Sammanfattning : In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. LÄS MER