Sökning: "inter-individual variability"

Visar resultat 1 - 5 av 64 avhandlingar innehållade orden inter-individual variability.

1. 1. Proteomics-informed analysis of drug disposition in the human liver and small intestine

   Författare :Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER

3. 2. The impact of genetics, environmental, and geographical factors on inter-individual and inter-ethnic differences in CYP2C9-catalysed drug metabolism

   Författare :Fazleen Haslinda Mohd Hatta; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Inter-individual and inter-ethnic variations in drug metabolism are creating an obstacle in providing efficient and effective drug treatments especially for drugs with narrow therapeutic windows. This thesis is contributes to the understanding of the molecular mechanism of these variations. LÄS MER

4. 3. Genetic variability and cadmium metabolism and toxicity

   Författare :Gerda Rentschler; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cadmium; polymorphism; TFRC; SLC39A8; SLC39A14; MT1A;

   Sammanfattning : Abstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. LÄS MER

5. 4. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

   Författare :João A. Abrantes; Mats Karlsson; Elisabet I. Nielsen; Siv Jönsson; Ron Mathôt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bayesian forecasting; coagulation factor VIII; dose adaptation; hemophilia haemophilia A; inter-occasion variability; NONMEM; pharmacodynamics; pharmacokinetics; pharmacometrics; therapeutic drug monitoring; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. LÄS MER

7. 5. Genetics and Labor Pain Behavior

   Författare :Fatimah Dabo Pettersson; Helena Åkerud; Inger Sundström Poromaa; Fred Nyberg; Pelle Lindqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anxiety; beta-endorphin; depressed mood; GCH1; labor analgesia; labor pain; OPRM1; SNP; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Labor may perhaps be the most painful a woman might experience, although characterized by large inter-individual variability. The perceived pain during labor is the result of diverse factors, i.e. her previous pain experiences, the analgesia she receives and maybe also her genes. LÄS MER