Sökning: "ximelagatran"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ximelagatran.

  1. 1. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

    Författare :Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; Uppsala universitet; []
    Nyckelord :Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

    Sammanfattning : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). LÄS MER

  3. 2. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

    Författare :Elin Matsson; Hans Lennernäs; Lars Knutson; Ulf Eriksson; Kim Brouwer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Direct thrombin inhibitors; prodrugs; ximelagatran; AZD0837; erythromycin; ketoconazole; drug-drug interactions; hepatobiliary transport; biliary clearance; ATP-binding cassette; ABC transporters; solute carriers; SLC transporters; CYP3A4; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. LÄS MER

  4. 3. Venous thromboembolism. Aspects on risk factors, diagnostic tools and treatment with thrombin inhibition

    Författare :Karin Wåhlander; Göteborgs universitet; []
    Nyckelord :deep vein thrombosis; pulmonary embolism; venous thromboembolism; Factor V Leiden; prothrombin gene G20210A; thrombin inhibition; ximelagatran; melagatran; PT; APTT; D-dimer.;

    Sammanfattning : Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease. The aims of the present thesis were to investigate Factor V Leiden and prothrombin G20210A mutations as potential risk factors for VTE during and after major surgery, to compare different D-dimer assays and evaluate their usefulness in the diagnosis of DVT, to investigate clinical effects, safety and pharmacokinetic properties of an oral thrombin inhibitor (ximelagatran) when treating VTE and finally to investigate the usefulness of coagulation assays (APTT and PT) during treatment with thrombin inhibition. LÄS MER

  5. 4. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

    Författare :Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. LÄS MER

  7. 5. Regulation of Tissue Factor and Coagulation Activity : Translation Studies with Focus on Platelet-Monocyte Aggregates and Patients with Acute Coronary Syndrome

    Författare :Christina Christersson; Agneta Siegbahn; Lars Wallentin; Jonas Oldgren; Ingebjorg Seljeflot; Uppsala universitet; []
    Nyckelord :Internal medicine; Myocardial infarction; Coagulation; Platelet-monocyte aggregates; Tissue factor; Thrombin inhibition; Invärtesmedicin;

    Sammanfattning : Myocardial infarction (MI) is often caused by a disruption of an atherosclerotic plaque with activation of coagulation, platelets and inflammation. The aims were; to investigate whether the oral direct thrombin inhibitor, ximelagatran affected markers for coagulation, platelet and inflammation in a patient cohort with recent MI and if the coagulation markers could identify patients with increased risk of new ischemic events; to evaluate some of the mechanisms involved in formation of platelet-monocyte aggregates (PMAs). LÄS MER