Sökning: "Christine Wegler"

Hittade 1 avhandling innehållade orden Christine Wegler.

1. 1. Proteomics-informed analysis of drug disposition in the human liver and small intestine

   Författare :Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER