Sökning: "antineoplastic drugs"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden antineoplastic drugs.

  1. 1. Monitoring of occupational exposure to antineoplastic drugs

    Författare :Maria Hedmer; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; industrial medicine; Occupational health; plasma; urine; renal clearance; risk evaluation; biological monitoring; air monitoring; wipe sampling; occupational exposure; ifosfamide; antineoplastic drugs; cyclophosphamide; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. LÄS MER

  3. 2. Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs

    Författare :Anna Nyhlén; Sektion III; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; neutropenic; antineoplastic agents; pharmacokinetics; pharmacodynamics; PAE; interactions; synergy; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; mykologi; virologi;

    Sammanfattning : The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on the intestinal microflora. LÄS MER

  4. 3. Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects

    Författare :Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. LÄS MER

  5. 4. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Författare :Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. LÄS MER

  7. 5. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue

    Författare :Juan Sebastián Yakisich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA replication - Cell cycle - Brain - Gliomas - Tissue mini-unit - Protein kinases - Proteases Inhibitors - Roscovitine;

    Sammanfattning : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. LÄS MER