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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract

   Författare :Björn Wullt; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteriology; Microbiology; asymptomatic bacteriuria; urinary tract infections; deliberate colonization; E. coli 83972; P-fimbriae; Mucosal host response; IL-6; IL-8; neutrophils; regulation.; GFP; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Bacterial adhesion to the bladder mucosa is a critical step for the establishment of Escherichia coli bacteriuria. The P-fimbriae, encoded by the pap gene cluster, are considered as virulence factors but the mechanisms have been debated. This study defined the roles for P fimbriation during the early colonization of the human urinary tract. LÄS MER

3. 2. Nitric oxide synthase in female reproductive and urinary organs: Hormonal regulation and functional significance

   Författare :Jassim Al-Hijji; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; Obstetrics; estrogen; trophoblast; placenta; vagina; Nitric oxide; uterus; ovarian steroids; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : Nitric oxide synthase (NOS) activity was studied in cytosolic and particulate fractions in reproductive organs from rabbit (uterus and vagina) and rat (uterus, vagina and cervix). NOS was found predominantly in cytosolic fractions in all tissues and the activity of NOS in both fractions was highly Ca2+ dependent. LÄS MER

4. 3. Towards improved management of Lynch syndrome; ovarian cancer profiles, risk perception, knowledge and family perspectives

   Författare :Katarina Bartuma; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; Lynch syndrome; family relations; communication; interview; genetic knowledge; risk perception; questionnaire; gene expression profiling; array CGH; hereditary breast and ovarian cancer; mismatch repair;

   Sammanfattning : Lynch syndrome (hereditary nonpolyposis colorectal cancer) is one of the most common hereditary cancer syndromes and predisposes to several cancer types, including cancer of the colorectum, endometrium and ovaries. Cancer develops at an early age and one third of the individuals are affected by a metachronous cancer. LÄS MER

5. 4. Role of TLR4 in Escherichia coli urinary tract infection

   Författare :Patrik Samuelsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; virologi; mycology; Mikrobiologi; bakteriologi; serologi; transplantation; Microbiology; virology; bacteriology; Immunologi; serology; Immunology; Pathogen; Mucosa; P-fimbriae; Toll like receptor;

   Sammanfattning : In this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. LÄS MER

7. 5. Hereditary Nonpolyposis Colorectal Cancer - Molecular Genetics and Biology of Associated Tumors

   Författare :Maria Planck; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endometrial cancer; rectal cancer; colon cancer; mismatch repair protein expression; coding repeats; microsatellite instability; MSH6; MSH2; Hereditary nonpolyposis colorectal cancer; MLH1; small bowel cancer; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

   Sammanfattning : This thesis focuses on one of the most common types of hereditary cancer, hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome is characterized by an autosomal dominant inheritance, an increased risk for several types of cancer (especially cancer of the colorectum, small bowel, endometrium, ovary and urinary tract), early age at diagnosis, and frequent development of multiple primary malignancies. LÄS MER