Sökning: "mismatch repair protein expression"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden mismatch repair protein expression.
- Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology
Sammanfattning : The tumour, node, metastasis (TNM) system, with the current staging and risk stratification methods for prognostication in colorectal cancer (CRC) has its limitations. The need for additional validated prognostic and predictive markers is particularly important in CRC stage II and III as some of these patients can be cured by surgery alone. LÄS MER
2. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch SyndromeDetta är en avhandling från Department of Oncology, Clinical Sciences, Lund University
Sammanfattning : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). LÄS MER
3. Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltrationDetta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology
Sammanfattning : Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy treatment, the disease-free-survival (DFS) rate for colon cancer is approximately 80% for stage II and for stage III close to 65%. LÄS MER
4. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancersDetta är en avhandling från Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Sammanfattning : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. LÄS MER
- Detta är en avhandling från Örebro : Örebro university
Sammanfattning : DNA methylation is an epigenetic mechanism that regulates the gene transcription. Folate is used in cellular synthesis of methyl groups, nucleic acids and amino acids. In complex diseases like cancer and neural tube defects (NTD), various genetic and epigenetic alterations can be found that disrupt the normal cell function. LÄS MER