Sökning: "Cisplatin resistance"
Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Cisplatin resistance.
1. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells
Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER
2. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance
Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER
3. Copper-transporting proteins and their interactions with platinum-based anticancer substances
Sammanfattning : Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER
4. Bacterial toxins for cancer treatment
Sammanfattning : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. LÄS MER
5. Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans
Sammanfattning : Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of all cells are non-dividing. LÄS MER