Sökning: "ASNA1"
Hittade 3 avhandlingar innehållade ordet ASNA1.
1. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells
Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER
2. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans
Sammanfattning : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. LÄS MER
3. Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans
Sammanfattning : ASNA1 is a well-conserved ATPase involved in a wide range of functions, including cisplatin resistance, growth control, insulin secretion and targeting of tail-anchored (TA) proteins to membranes. It is a positive regulator of insulin secretion both in the roundworm Caenorhabditis elegans and in humans. LÄS MER