Sökning: "Protein Structure"

Visar resultat 1 - 5 av 1335 avhandlingar innehållade orden Protein Structure.

  1. 1. Protein structure prediction Zinc-binding sites, one-dimensional structure and remote homology

    Detta är en avhandling från Stockholm : Department of Materials and Environmental Chemistry (MMK), Stockholm University

    Författare :Nanjiang Shu; Stockholms universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; zinc-binding; profile; homology detection; shape string; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; Structural Chemistry; strukturkemi;

    Sammanfattning : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. LÄS MER

  2. 2. Molecular principles of protein stability and protein-protein interactions

    Detta är en avhandling från Stockholm : KTH

    Författare :Christofer Lendel; KTH.; [2005]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

  3. 3. Protein Structure Prediction Model Building and Quality Assessment

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Björn Wallner; Stockholms universitet.; [2005]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; proteinstrukturförutsägelse; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik;

    Sammanfattning : Proteins play a crucial roll in all biological processes. The wide range of protein functions is made possible through the many different conformations that the protein chain can adopt. The structure of a protein is extremely important for its function, but to determine the structure of protein experimentally is both difficult and time consuming. LÄS MER

  4. 4. Structure determination and thermodynamic stabilization of an engineered protein-protein complex

    Detta är en avhandling från Stockholm : KTH

    Författare :Elisabet Wahlberg; KTH.; [2006]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; protein structure; coupled folding; NMR spectroscopy; protein stability; protein-protein interactions; binding thermodynamics; isothermal titration calorimetry; protein engineering; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Sammanfattning : The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. LÄS MER

  5. 5. Protein complexes assembly, structure and function

    Detta är en avhandling från Umeå : Umeå university

    Författare :Kristina Wilhelm; Umeå universitet.; [2009]
    Nyckelord :HAMLET; ELOA; lysozyme; amyloid; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. LÄS MER