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Visar resultat 11 - 15 av 50 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Regulation of innate and acquired immunity in infants by commensal bacteria

    Författare :Helen Karlsson; Göteborgs universitet; []
    Nyckelord :intestinal microflora; commensal; antigen-presenting cells; dendritic cells; CD25 regulatory T cells; allergy; infants; Staphylococcus aureus;

    Sammanfattning : The incidence of atopic diseases in children is steadily increasing in the industrialised world along with an improved hygienic lifestyle. The gastrointestinal flora may be of specific importance for the proper maturation of the immune system and for the induction of tolerance, in which CD25+ regulatory T cells (Tregs) play a crucial role. LÄS MER

  3. 12. Costimulation Blockade in Experimental Transplantation

    Författare :Helene Malm; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; serologi; Immunologi; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; graft survival; anti-CD40L; CTLA4Ig; anti-LFA-1; costimulation blockade;

    Sammanfattning : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. LÄS MER

  4. 13. On the induction and function of Foxp3+ regulatory T cells

    Författare :Cecilia Oderup; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; regulatory T cell; serology; Immunology; superantigen; costimulation; dendritic cell; Foxp3;

    Sammanfattning : This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. LÄS MER

  5. 14. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

    Författare :Edward Visse; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. LÄS MER

  7. 15. On the regulation of immune responses to dietary and self antigens

    Författare :Susanne Lindgren; Göteborgs universitet; []
    Nyckelord :Tolerance; regulatory T cells; self antigens; oral tolerance; dietary antigens; intestinal epithelial cells; exosomes; Staphylococcus aureus enterotoxin A;

    Sammanfattning : Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for this regulation. We investigated if CD4+CD25+ Treg prevents auto-reactive responses in adult peripheral blood and cord blood. LÄS MER