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Visar resultat 16 - 20 av 50 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Immune profile from high-risk to onset of Type 1 diabetes

    Författare :Anna Rydén; Maria Faresjö; Johnny Ludvigsson; Malin Flodström-Tullberg; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Type 1 diabetes (T1D) is most often diagnosed early in life and is usually the result of an autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. LÄS MER

  3. 17. CNS-Targeted Cell Therapy for Multiple Sclerosis

    Författare :Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. LÄS MER

  4. 18. Studies of immunological risk factors in type 1 diabetes

    Författare :Jenny Walldén (Fredriksson); Outi Vaarala; Johnny Ludvigsson; Vivianne Malmström; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi;

    Sammanfattning : Background: Type 1 diabetes (T1D) is a chronic, autoimmune disease caused by a T cell mediated destruction of ß-cells in pancreas. The development of T1D is determined by a combination of genetic susceptibility genes and environmental factors involved in the pathogenesis of T1D. LÄS MER

  5. 19. Genetic and immunological control of human myasthenia gravis

    Författare :Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Sammanfattning : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. LÄS MER

  7. 20. On immunotherapy against prostate cancer

    Författare :Kajsa Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer (PC) is the most frequently diagnosed cancer in Swedish men, with an incidence of around 9000 cases per year, and the main cause of cancer related death. Standard treatment includes surgery, radiotherapy and hormonal therapy. LÄS MER