Sökning: "costimulation blockade"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden costimulation blockade.

  1. 1. Costimulation Blockade in Experimental Transplantation

    Författare :Helene Malm; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; serologi; Immunologi; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; graft survival; anti-CD40L; CTLA4Ig; anti-LFA-1; costimulation blockade;

    Sammanfattning : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. LÄS MER

  3. 2. Peripheral nerve reconstruction. Studies on cellular and acellular iso-, allo- and xenografts

    Författare :Martin Kvist; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acellular nerve graft; costimulation blockade; FK506; immunosuppression; nerve graft; nerve defect; nerve regeneration; nerve injury; nerve extraction; allograft; xenograft;

    Sammanfattning : The best results after a nerve injury with a defect are achieved by a nerve reconstruction procedure using autologous nerve grafts. However, limitations include insufficient amount of suitable donor material and donor site morbidity. The aim of the present thesis was to study alternative nerve grafts, i.e. LÄS MER

  4. 3. On the induction and function of Foxp3+ regulatory T cells

    Författare :Cecilia Oderup; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; regulatory T cell; serology; Immunology; superantigen; costimulation; dendritic cell; Foxp3;

    Sammanfattning : This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. LÄS MER

  5. 4. Experimental islet transplantation

    Författare :Randa A Hadi Gadalla Diab; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic islet transplantation is a promising treatment modality for patients with insulin- dependent diabetes. Besides whole pancreas transplantation, it is the only treatment that can make patients normoglycemic without risking episodes of hypoglycemia. LÄS MER

  7. 5. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells

    Författare :Karin Ljung; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER