Sökning: "superantigen"

Visar resultat 1 - 5 av 34 avhandlingar innehållade ordet superantigen.

  1. 1. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12

    Författare :Yun Jiang; Peter Mathieson; Stockholms universitet; []

    Sammanfattning : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. LÄS MER

  2. 2. Staphylococcal enterotoxin H - structure and function of a superantigen

    Författare :Helen Pettersson; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; TCR; staphylococcal enterotoxin H; MHC class II; superantigen; transplantation; Immunologi; serologi; serology;

    Sammanfattning : The aim of this thesis was to characterise the biological functions of the superantigen staphylococcal enterotoxin H (SEH). Superantigens are highly immunostimulatory proteins, which crosslink T cells and antigen presenting cells (APCs). LÄS MER

  3. 3. The immunomodulatory function of staphylococcal superantigen on oral tolerance

    Författare :Anna Stern; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; oral tolerance; superantigen; hygiene hypothesis; staphylococcal enterotoxin;

    Sammanfattning : Exposure to soluble proteins via the gut gives rise to systemic tolerance, a phenomenon called oral tolerance. Failure of oral tolerance results in allergy, a disease that has increased during the last decades in Western industrialized countries. The cause of this rapid increase is unknown. LÄS MER

  4. 4. Interplay between superantigens and immunoreceptors

    Författare :Karin Lindkvist; Medicinsk strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; serology; Immunology; TCR; MHC class II; X-ray crystallography; superantigen; staphylococcal enterotoxin; Biofysik; transplantation; Immunologi; serologi; Biophysics;

    Sammanfattning : This thesis deals with the interactions between superantigens and their receptors. Superantigens are proteins that are secreted by various bacteria, such as Staphylococcus aureus and Streptococcus pyogenes. Superantigens are able to cross-link T cells and antigen presenting cells by binding to the T cell receptor (TCR) and MHC class II. LÄS MER

  5. 5. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Författare :Karin Rödström; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Sammanfattning : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. LÄS MER