Sökning: "receptor expression"
Visar resultat 1 - 5 av 2048 avhandlingar innehållade orden receptor expression.
1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
Sammanfattning : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. LÄS MER
2. Studies of a Proteinase-activated Cell Surface Receptor
Sammanfattning : The G protein-coupled receptors form one of the largest families of proteins involved in signalling between cells. It contains receptors for molecules as diverse as biogenic amines, glycoproteins and enzymes. The manuscripts included in this thesis together describe the initial characterisation of a previously unknown receptor of this class. LÄS MER
3. Galanin receptor ligands
Sammanfattning : In the nervous system galanin primarily displays a modulatory role. The galaninergic system consists of a number of bioactive peptides with a highly plastic expression pattern and three different receptors. The lack of receptor subtype selective ligands and antibodies have severely hampered the charac-terization of this system. LÄS MER
4. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r
Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER
5. Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
Sammanfattning : The present thesis is aimed to examine the hypothesis that the degree of vascular inflammation correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). LÄS MER