Sökning: "PAR-2"

Hittade 5 avhandlingar innehållade ordet PAR-2.

  1. 1. Studies of a Proteinase-activated Cell Surface Receptor

    Författare :Sverker Nystedt; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor; proteinase; PAR-2; molecular cloning; in situ hybridisation; Expression; G-protein; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The G protein-coupled receptors form one of the largest families of proteins involved in signalling between cells. It contains receptors for molecules as diverse as biogenic amines, glycoproteins and enzymes. The manuscripts included in this thesis together describe the initial characterisation of a previously unknown receptor of this class. LÄS MER

  3. 2. Aspects of proteinase-activated receptor-2: A sensor of enzymatic activity at the cell surface

    Författare :Anna-Karin Alm; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; endometrium.; coagulation; signalling; proteinase; G-protein; cell; receptor; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Information about extracellular proteolytic activity is transduced to the cell by a transmembrane G-protein coupled receptor subfamily. These receptors are activated by proteolytic cleavage in the extracellular amino-terminal domain and are thus termed proteinase-activated receptors (PARs). LÄS MER

  4. 3. Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets

    Författare :Rajesh Kumar; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type II Diabetes; GPCR; Pancreatic islets; Estrogen; Alpha-1 antitrypsin.;

    Sammanfattning : The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. LÄS MER

  5. 4. Kallikrein-related peptidases in human epidermis : studies on activity, regulation, and function

    Författare :Kristina Stefansson; Torbjörn Egelrud; Maria Brattsand; Mona Ståhle; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). LÄS MER

  7. 5. Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms

    Författare :Resti Rudjito; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles to overcome as a significant proportion of patients still report continuous pain. LÄS MER