Sökning: "melanocortin 4 receptor"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden melanocortin 4 receptor.
1. Cloning, Expression, Pharmacological Characterization and Anatomical Distribution of Melanocortin Receptors in an Evolutionary Perspective
Sammanfattning : The melanocortin (MC) receptors are G-protein coupled receptors thatparticipate in several important physiological functions such as the regulation of the energy balance. This thesis focuses on the evolutionary aspect of the MC receptors and their pharmacology.One MC4 receptor and two MC5 receptor subtypes were found in a teleost fish, zebrafish. LÄS MER
2. Molecular Mechanisms of Reward and Aversion
Sammanfattning : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. LÄS MER
3. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r
Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER
4. Neurotrophic Factor Receptors in the Normal and Injured Visual System : Focus on Retinal Ganglion Cells
Sammanfattning : The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. LÄS MER
5. Brain Stem Involvement in Immune and Aversive Challenge
Sammanfattning : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. LÄS MER