Sökning: "exposure in vivo"

Visar resultat 1 - 5 av 363 avhandlingar innehållade orden exposure in vivo.

  1. 1. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Markus Fridén; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. LÄS MER

  2. 2. Engineered nanomaterials in in vivo and in vitro models

    Detta är en avhandling från Department of Physics, Lund University

    Författare :Laura Abariute; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; III-V semiconductor nanowires; Nanoparticle exposure; Mouse exposure; Cell exposure; Nanotoxicology; Nanosafety; Fysicumarkivet A:2018:Abariute;

    Sammanfattning : Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. LÄS MER

  3. 3. Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo

    Detta är en avhandling från Medical Radiation Physics, Lund University

    Författare :Jimmy Börjesson; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physics; exposure assessment; smelter; half-time; fingerbone; occupational exposure; bone; thyroid; liver; kidney cortex; lead; mercury; cadmium; XRF; in vivo; Fysik; Chemistry; Kemi;

    Sammanfattning : Two XRF methods have been used for in vivo studies of mercury, cadmium and lead. Persons with a history of long-term occupational mercury exposure had elevated mercury concentrations in their kidneys (up to 65 µg/g). The minimum detectable concentration varied between 12 and 45 µg/g. LÄS MER

  4. 4. Stuck in mind the role of catastrophizing in pain

    Detta är en avhandling från Örebro : Örebro universitet

    Författare :Ida K. Flink; Örebro universitet.; [2011]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; catastrophizing; pain; fear avoidance; problem solving; Psykologi; Psychology;

    Sammanfattning : Pain catastrophizing emerges in the literature as one of the most important psychological determinants of both pain itself and the negative outcomes commonly associated with it. However, despite decades of research confirming the impact of catastrophizing, there are still areas that remain unexplored or in which the surface has only been scratched. LÄS MER

  5. 5. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs a Study Involving in silico, in vitro and in vivo Assessment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Carlert; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER