Sökning: "muskulatur"

Visar resultat 1 - 5 av 56 avhandlingar innehållade ordet muskulatur.

1. 1. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

   Författare :Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

   Sammanfattning : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. LÄS MER

3. 2. Variability and adaptation in the contractile system of smooth muscle

   Författare :Mia Löfgren; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; essential light chain; desmin; shortening velocity; integrin; intermediate filament; hypertrophy; non-muscle myosin; smooth muscle; myosin; heavy chain; Physiology; Fysiologi;

   Sammanfattning : This thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). LÄS MER

4. 3. The Influence of Physical Activity on Musculoskeletal Characteristics and Fracture Risk at Growth

   Författare :Fredrik Detter; Ortopedi - klinisk och molekylär osteoporosforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BMC; BMD; pQCT; DXA; Fractures; Children; Bone; Muscle;

   Sammanfattning : Physical Activity (PA) can improve neuromuscular development. A high level of physical activity can perhaps however lead to more fractures. This is a longitudinal population-based exercise intervention study where the school-based physical education (PE) in one school is increased from mean 60 min/week to mean 200 min/ week. LÄS MER

5. 4. Regulation of inducible nitric oxide synthase - Consequences in experimental models of bladder disease

   Författare :Rebecka Johansson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Farmakologi; smooth muscle-myosin heavy chain; Pharmacological sciences; pharmacognosy; farmakognosi; farmaci; actin; BDNF; Rho; aminoguanidine; TNF-alpha; IL-1beta; hypertrophy; differentiation; smooth muscle; bladder; nitric oxide; inducible nitric oxide synthase; toxikologi;

   Sammanfattning : Inducible nitric oxide synthase (iNOS) expression is associated with various pathophysiological conditions in the lower urinary tract. The aims of this thesis have been to investigate the regulation of iNOS in bladder smooth muscle cells and the consequences on neuromuscular regulation, cell growth and differentiation. LÄS MER

7. 5. Calcium channel activity and force regulation in smooth muscle: Effects of polyamines and growth stimulation

   Författare :Maria Gomez; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; verapamil; tissue culture; portal vein; patch-clamp; calcium; spermidine; spermine; polyamines; excitation-contraction; smooth muscle; calcium channel; ionomycin.; Physiology; Fysiologi;

   Sammanfattning : The initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. LÄS MER