Sökning: "intermediate filament"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden intermediate filament.

  1. 1. Filament assembly and structural studies of intermediate filament like protein, FilP, in Streptomyces coelicolor

    Författare :Ala Javadi; Linda Sandblad; Martin Thanbichler; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cytoskeleton; Intermediate filament-like; FilP; Streptomyces coelicolor; filament assembly; cryoelectron tomography; single particle analysis; crystallography; cellulose affinity;

    Sammanfattning : The cytoskeleton, known as intracellular connected filaments, has a prominent role in cellular behavior, motility, and stability. The following three major types of polymers have been characterized as cytoskeleton in eukaryotes: microtubules that are 25 nm in diameter, actin filaments that are 7 nm in diameter, and intermediate filaments (IF) that are 10 nm in diameter. LÄS MER

  2. 2. On the mechanics of actin and intermediate filament networks and their contribution to cellular mechanics

    Författare :Björn Fallqvist; Kroon Martin; Peter McHugh; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; actin; cell; mechanical; constitutive; intermediate; continuum; constitutive; Solid Mechanics; Hållfasthetslära;

    Sammanfattning : The mechanical behaviour of cells is essential in ensuring continued physiological function, and deficiencies therein can result in a variety of diseases. Also, altered mechanical response of cells can in certain cases be an indicator of a diseased state, and even actively promoting progression of pathology. LÄS MER

  3. 3. Variability and adaptation in the contractile system of smooth muscle

    Författare :Mia Löfgren; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; essential light chain; desmin; shortening velocity; integrin; intermediate filament; hypertrophy; non-muscle myosin; smooth muscle; myosin; heavy chain; Physiology; Fysiologi;

    Sammanfattning : This thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). LÄS MER

  4. 4. Role of intermediate filament desmin in development of desmin-related myopathy

    Författare :Natalia Smolina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Desmin is a major intermediate filament of muscle cells, serving to transmit mechanical forces and propagate mechanochemical signals, to coordinate contraction and relaxation cycles, and to stabilize the positioning of cellular organelles, e.g. mitochondria. LÄS MER

  5. 5. Nestin : filament formation and expression in myogenesis and muscle disorders

    Författare :Gunnar Sjöberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Intermediate filament; nestin; desmin; vimentin; myogenesis neuromusculardisorders; rhabdomyosarcoma;

    Sammanfattning : NESTIN: FILAMENT FORMATION AND EXPRESSION IN MYOGENESIS ANDMUSCLE DISORDERS Gunnar Sjöberg Department of Cell and Molecular Biology, Karolinska InstitutetStockholm Intermediate filaments (IF), together with microfilaments and microtubules, arethe major components of the cytoskeleton of eukaryotic cells. In myogenic cells threeIF proteins are expressed; desmin, vimentin and nestin. LÄS MER