Sökning: "ionomycin."

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet ionomycin..

1. 1. Calcium channel activity and force regulation in smooth muscle: Effects of polyamines and growth stimulation

   Författare :Maria Gomez; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; verapamil; tissue culture; portal vein; patch-clamp; calcium; spermidine; spermine; polyamines; excitation-contraction; smooth muscle; calcium channel; ionomycin.; Physiology; Fysiologi;

   Sammanfattning : The initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. LÄS MER

3. 2. Modulation of the calcium-force relationship in smooth muscle by polyamines and metabolic inhibition

   Författare :Karl Swärd; Cellulär biomekanik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic inhibition; polyamines; excitation-contraction coupling; smooth muscle; intracellular calcium; Physiology; Fysiologi;

   Sammanfattning : The relationship between intracellular free calcium ([Ca2+]i) and force in smooth muscle was investigated in receptor-coupled permeabilized preparations and by fluorimetry of the calcium indicator Fura 2 in intact smooth muscle. The time integral of spontaneous [Ca2+]i transients in the intact rat portal vein was decreased by cyanide and, during tonic contraction, cyanide reduced force without changing [Ca2+]i implying metabolic sensitivity of both membrane excitation and [Ca2+]i - activation of the contractile proteins. LÄS MER

4. 3. Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies

   Författare :Joanna Sara Kritikou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in immune cells and their role in tumorigenesis. LÄS MER

5. 4. Ion transport in exocrine glands with reference to cystic fibrosis

   Författare :Ailing Zhang; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ion transport; cystic fibrosis; submandibular gland; airway submucosal gland; X-ray microanalysis; cytosolic Ca2 concentration; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

   Sammanfattning : Aspects of ion transport in rat submandibular gland acinar cells at the subcellular level, and the regulation of chloride secretion and calcium mobilization in cultured pig tracheal gland acinar cells were studied with reference to the disease cystic fibrosis.In adult rat submandibular gland acinar cells, both cholinergic and α-adrenergic stimulation induced efflux of K+ and of C1-, but the response was generally less with α-adrenergic stimulation. LÄS MER

7. 5. Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs

   Författare :Anne Kling-Petersen; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidation NSAIDs ASA dexamethasone apoptosis GSH GSSG proteasome lens epithelial cells mouse lens cataract;

   Sammanfattning : Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses. LÄS MER