Sökning: "in vitro testing"

Visar resultat 6 - 10 av 165 avhandlingar innehållade orden in vitro testing.

  1. 6. Developmental Neurotoxicity Testing Using In vitro Approaches

    Författare :Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Sammanfattning : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. LÄS MER

  3. 7. Actomyosin in biocomputation

    Författare :Aseem Salhotra; Alf Månsson; Henry Hess; Linnéuniversitetet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; biocomputation; molecular motors; 3-SAT; surface chemistry; actomyosin; actin; myosin II; heavy meromyosin; myosin XI; engineered myosin; in vitro motility assay; nanofabrication; alternate computing; network based biocomputation; protein-surface interaction; longevity; prolongation; surface recycling; affinity purification; blocking actin; Bioteknik; Biotechnology; Biokemi; Biochemistry;

    Sammanfattning : There exist complex mathematical problems that are important in real world applications such as weather prediction, molecular modelling, network route optimization and more. In general, such problems are solved using supercomputers with higher computing efficiency but this also consumes high energy along with high production and maintenance cost. LÄS MER

  4. 8. Cerebrospinal Fluid Shunts in Children : Technical Considerations and Treatment of Certain Complications

    Författare :Kai Arnell; Tomas Wester; Jan Sjölin; Per Enblad; Hans C-son Silander; Uppsala universitet; []
    Nyckelord :Surgery; Hydrocephalus; papilloedema; abdominal cyst; cerebrospinal fluid shunt; shunt infection; intraventricular antibiotic instillation; intraventricular antibiotic concentrations; in-vitro testing; antisiphon device; Kirurgi;

    Sammanfattning : Ventriculo-peritoneal shunting is the most commonly used method for the treatment of paediatric hydrocephalus. Despite improved shunts and surgical techniques there are still complications. This retrospective study focuses on diagnoses and treatment of shunt malfunction and infections. Cost/benefit of using an adjustable shunt was assessed. LÄS MER

  5. 9. Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective

    Författare :Klara Midander; Inger Odnevall Wallinder; Sannakaisa Virtanen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ferro-chromium alloy; metal particles; bioaccessibility; chemical speciation; dermal contact; surface oxide; in-vitro testing; chemical speciation; cu; copper; comet assay; intracellular; ultrafine; in vitro; A549; cytotoxicity; DNA damage; nanoparticles; particle characterization; artificial sweat; nickel release; nickel powder particles; particle loadings; release kinetics; surface area; copper release; powder particles; synthetic body fluids; simulation of interstitial lung conditions; skin contact; metal release; stainless steel; particles; test method; Surface and colloid chemistry; Yt- och kolloidkemi; Analytical chemistry; Analytisk kemi; Spectroscopy; Spektroskopi;

    Sammanfattning : Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact. Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms. LÄS MER

  7. 10. In vitro toxicity testing using human pluripotent stem cell derivatives

    Författare :Gustav Holmgren; Anders Lindahl; Jane Synnergren; Peter Sartipy; Chris Denning; Sahlgrenska Academy at University of Gothenburg; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicity testing; human pluripotent stem cells; cardiomyocytes; hepatocytes; microarray; quantitative proteomics; bioinformatics; transcriptomics; microRNA; Medical sciences; Medicin; Bioinformatik; Bioinformatics;

    Sammanfattning : .... LÄS MER