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Visar resultat 21 - 25 av 285 avhandlingar som matchar ovanstående sökkriterier.
21. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study
Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER
22. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family
Sammanfattning : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. LÄS MER
23. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. LÄS MER
24. Expression and Regulation of P2 Receptors in Human Circulation
Sammanfattning : P2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP and UDP regulating several physiological responses including cardiac function, vascular tone, smooth muscle cell (SMC) proliferation, platelet aggregation, and the release of endothelial factors. The aim of the present study was to investigate the mRNA and protein expression of P2 receptors in human SMCs, endothelial cells (ECs), erythrocytes and platelets, the regulation of P2 receptors under shear stress in human vessels, the changes of platelet P2 receptors in patients with systemic lupus erythematosus (SLE) and the regulation of plasma ATP levels by P2 receptor on erythrocytes. LÄS MER
25. Vacuum-assisted closure in cardiac surgery - clinical outcome and vascular effects
Sammanfattning : The aim of this research was to clinically and experimentally evaluate the use of vacuum-assisted closure in poststernotomy mediastinitis after cardiac surgery. Vacuum-assisted closure (VAC) is a new wound-healing therapy based on the application of a local negative pressure to the wound. LÄS MER