Sökning: "antihypertensive agents"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden antihypertensive agents.

  1. 1. Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy

    Författare :Tove Bokrantz; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :epidemiology; hypertension; antihypertensive agents; fractures; peripheral arterial disease; bone density;

    Sammanfattning : Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood pressure might affect the risk for fractures. Methods and results: In Study I and II, the associations between different antihypertensive treatments and fracture risk were investigated in a cohort of about 60. LÄS MER

  2. 2. Antihypertensive treatment and endothelial vasodilatory function

    Författare :Bengt von zur Mühlen; Uppsala universitet; []
    Nyckelord :Medical sciences; Hypertension; endothelium; nitric oxide; antihypertensive treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The endothelium integrates vascular tone by the synthesis of vasoactive substances secreted abluminally to the underlying vascular smooth muscle. Endothelial function has previously been shown to be impaired in primary, secondary and experimental forms of hypertension. LÄS MER

  3. 3. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis

    Författare :Wilhelm Ridderstråle; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :hypertension; left ventricular hypertrophy; intima-media thickness; fibrinolysis; endothelium; tissue plasminogen activator; antihypertensive agents; mechanical stress; plasminogen activator inhibitor-1;

    Sammanfattning : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. LÄS MER

  4. 4. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease

    Författare :Erik Ulfhammer; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :tissue-type plasminogen activator; endothelium; fibrinolysis; hypertension; shear stress; strain; antihypertensive agents; inflammation; TNF-alpha; NF-kappaB; MAPK;

    Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. LÄS MER

  5. 5. Endothelium-dependent vasodilation in essential hypertension

    Författare :Jonas Millgård; Uppsala universitet; []
    Nyckelord :Medical sciences; endothelium; hypertension; human; blood pressure; vasodilation; ACE-inhibition; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Internal Medicine; invärtesmedicin;

    Sammanfattning : The vascular endothelium plays a crucial role in the regulation of several homeostatic parameters in the circulation. In this thesis, the influences of essential hypertension and antihypertensive agents on endothelium-dependent vasodilation (EDV) were evaluated in the human forearm circulation. LÄS MER