Sökning: "Sensing mechanism"

Visar resultat 11 - 15 av 120 avhandlingar innehållade orden Sensing mechanism.

1. 11. Nutrient and energy sensing in skeletal muscle

   Författare :Atul S Deshmukh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle; AMPK; mTOR; glucose metabolism; exercise; Akt; TBC1D1 D4; CaMK; NO-cGMP;

   Sammanfattning : Nutrient overload and physical inactivity often leads to the development of obesity and type 2 diabetes. Acute over-nutrition can induce insulin resistance, while physical exercise enhances skeletal muscle insulin sensitivity. Like every living cell, skeletal muscle senses nutrient and energy signals and to adjust metabolic flux. LÄS MER

3. 12. Investigation of electrochemical properties and performance of stimulation/sensing electrodes for pacemaker applications

   Författare :Anna Norlin; Jinshan Pan; Dieter Scharnweber; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; pacemaker electrode; interfacial property; biomaterial; electrostimulation charge transfer mechanism; electrochemical impedance spectroscopy; transient processes; plasma electrolysis anodisation; porous niobium oxide; ruthenium oxide; nano-porous carbon; iridium oxide; titanium nitride; platinum; surface roughness; porous electrode; pacing impedance; electrode polarisation; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi;

   Sammanfattning : People suffering from certain types of arrhythmia may benefit from the implantation of a cardiac pacemaker. Pacemakers artificially stimulate the heart by applying short electrical pulses to the cardiac tissue to restore and maintain a steady heart rhythm. By adjusting the pulse delivery rate the heart is stimulated to beat at desired pace. LÄS MER

4. 13. Intracellular components involved in parathyroid sensing of extracellular calcium

   Författare :Isaac G. Onyango; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Parathyroid hormone; secretion; Src kinase; ERK; PI 3-kinase; PKC; extracellular calcium; parathyroid cell; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

   Sammanfattning : Parathyroid glands are the primary regulator of extracellular calcium ([Ca2+]e). Ca2+ plays a key role in many fundamental biological processes and is also an essential structural component of the skeleton. The parathyroid chief cells detect small changes in [Ca2+]e and respond by altering the secretion of parathyroid hormone (PTH). LÄS MER

5. 14. Towards specific quantification of exosomes using surface-based sensing

   Författare :Deborah Rupert; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; label-free; surface plasmon resonance.; exosome; binding rate; antibody; concentration; nanoparticle tracking analysis; quantification; liposome; cluster of differentiation 63 CD63 ; diffusion; specific detection; mass transport limited conditions; extracellular vesicles; surface-based biosensor;

   Sammanfattning : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. LÄS MER

7. 15. Stress response and virulence in Vibrio anguillarum

   Författare :Barbara Weber; Debra L. Milton; James D. Oliver; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Vibrio anguillarum; quorum sensing; Type VI secretion; stress response; virulence; skin colonization; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Bacteria use quorum sensing, a cell to cell signaling mechanism mediated by small molecules that are produced by specific signal molecule synthases, to regulate gene expression in response to population density. In Vibrio anguillarum, the quorum-sensing phosphorelay channels information from three hybrid sensor kinases VanN, VanQ, CqsS that sense signal molecules produced by the synthases VanM, VanS and CqsA, onto the phosphotransferase VanU, to regulate activity of the response regulator VanO. LÄS MER